• Second although it is an important and biologically plausibl

  2019-05-05

  

  Second, although it is an important and biologically plausible refinement, risk-factor adjustment based on lack of access to improved water in rural areas and urban slums could be open to criticism, as the authors acknowledge. The imperfect relation between access to improved water and consumption o

• br Conclusions br Acknowledgements This work was supported b

  2019-05-04

  

  Conclusions Acknowledgements This work was supported by Bloodwise, the International Myeloma Foundation and a Marie Curie Career Integration Grant from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [294160]. The osteoblast in normal bone physiology

• The clinical spectrum of intracranial hemorrhage is similar

  2019-05-04

  

  The clinical spectrum of intracranial hemorrhage is similar for patients treated with warfarin and dabigatran [10]. Absolute rates of intracranial hemorrhage across all sites and of both fatal and traumatic intracranial hemorrhages are lower with dabigatran than with warfarin [10]. Concomitant aspir

• Involvement of the ventricular myocardium can

  2019-05-04

  

  Involvement of the ventricular myocardium can lead to delayed conduction or anatomical obstacles that are labile to ventricular tachyarrhythmia. Arrhythmias are independently predictive of sudden cardiac death (SCD) [9]. SCD is common in patients with cardiac AL amyloidosis, and prophylactic implant

• RANK RANKL The RANK RANKL signaling pathway is

  2019-05-04

  

  RANK/RANKL: The RANK/RANKL signaling pathway is a critical component of both normal and malignant bone remodeling. RANK is a transmembrane signaling receptor and a member of the tumor necrosis receptor (TNF) superfamily that is found on the surface of OCL precursors [43,44]. RANK ligand (RANKL) is e

• br Methods br Results br Discussion The results

  2019-05-04

  

  Methods Results Discussion The results of this study demonstrate that (1) low-dose landiolol (0.5μgkg−1min−1) prevent heart rate elevation after AF ablation; (2) prophylactic administration of low-dose landiolol successfully prevented immediate AF recurrence within 3d after AF ablation with

• Concurrent with the clinical evaluation

  2019-05-04

  

  Concurrent with the clinical evaluation of the family, the genetic findings from a molecular autopsy may help to elucidate the cause of death in the decedent, as well as provide a basis for cascade genetic testing of at-risk family members. Offering cascade genetic testing to asymptomatic relatives

• To assess quality independent from quantity Imamura and

  2019-05-04

  

  To assess quality independent from quantity, Imamura and colleagues assessed dietary intake adjusted for 2000 kcal per day. An unfortunate consequence of this adjustment is that the role of unrestrained energy intake in the obesity and diabetes epidemics seems to be rendered obsolete. For example, i

• br Conclusions br Financial support

  2019-05-04

  

  Conclusions Financial support Conflict of interest Acknowledgment Introduction Cardiac resynchronization therapy (CRT) has been demonstrated to improve symptoms, quality of life, functional status, and reduce mortality and Spadin failure-related hospitalizations in patients with New Y

• caspase pathway Una de las teor as m s

  2019-04-30

  

  Una de las teorías más destacadas sobre el género lo emparenta con el proyecto que llevaron caspase pathway cabo autores alemanes como Bertold Brecht o Walter Benjamin, quienes: Ana María Amar Sánchez, teórica que propone esta línea genealógica para explicar la creación testimonial del argentino Ro

• Upper gastrointestinal bleeding secondary to peptic ulcer di

  2019-04-30

  

  Upper gastrointestinal bleeding secondary to peptic ulcer disease is a common life-threatening medical condition. However, historically, peptic ulcer disease was an uncommon ailment. The rise in the incidence of peptic ulcer disease occurred in the mid-1800s. At that time, studies in North America a

• Interpretation Haitian children have unacceptable rates of r

  2019-04-30

  

  Interpretation Haitian children have unacceptable rates of raised blood lead concentrations, with an unexplained disproportionate elevation in children living in the Centre department. Our findings suggest that routine, widespread screening, detailed investigation into modifiable risk factors, targe

• Permanent pacemaker implantation with trans IVC access was f

  2019-04-30

  

  Permanent pacemaker implantation with trans-IVC access was first reported in 23 cases by Ellestad et al., in 1980 [2]; it was then reported in 95 cases, of which the early cases were published in 1989 by the same author as the largest series reported thus far [5]. Mathur et al. also reported 27 case

• The most compelling apparent evidence in support

  2019-04-30

  

  The most compelling apparent evidence in support of the depolarization hypothesis derives from the seminal studies of Nademanee et al. [129]. showing that radiofrequency ablation (RFA) of epicardial sites displaying late potentials and fractionated bipolar electrograms in the RVOT of patients with B

• Heat shock facilitates the folding

  2019-04-30

  

  Heat shock facilitates the folding of various proteins as mediated by the HSP family and can stabilize mutant proteins. HS has been reported to facilitate maturation of WT-HERG as well as mutant HERG by activating the HSF family [15]. HSF-1, 2, and 4 were reported to be expressed in humans. HSF-1 is

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