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Programmed death ligand PD L expression is a
2019-05-08
Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed
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br Should child growth replace diarrhoea as
2019-05-07
Should child growth replace diarrhoea as the primary child health outcome for sanitation trials? We appreciate Derek Headey\'s comment in relation to our trial that the window of opportunity to plausibly affect growth faltering is from in utero up to 24 months, and therefore that sanitation trials
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In response to the lack of epidemiological
2019-05-07
In response to the lack of epidemiological information on typhoid in Africa, the Typhoid Fever Surveillance in Africa Programme (TSAP), funded by the Bill & Melinda Gates Foundation and covering ten countries and 13 sites across Africa, was established between 2010 and 2014. In this ionophores issu
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After being secreted into bile and entering
2019-05-07
After being secreted into bile and entering the intestine, ∼95% of the bile acids are returned to the liver through the enterohepatic circulation via an active transport and Cyclopamine by a specific bile acid transporter, apical sodium-dependent bile acid transporter predominantly in the distal ile
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Introduction Schwannoma is a benign tumor of neuroectodermal
2019-05-07
Introduction Schwannoma is a benign tumor of neuroectodermal derivation that originates from Schwann cell cycle arrest which cover the peripheral nerves [3]. Approximately 25–40% of all schwannomas occur in the head and neck. These tumors most commonly arise in the soft tissues of the head and nec
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br Patients and methods br Discussion In this secondary endp
2019-05-07
Patients and methods Discussion In this cetrimonium bromide secondary endpoint analysis of the OPTION trial, we have shown that the addition of goserelin to neo(adjuvant) chemotherapy temporarily increased bone turnover during treatment and that this reverses over the next 6–12 months after c
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Although the NCCN IPI is a promising
2019-05-07
Although the NCCN-IPI is a promising simple scale based on conventional clinical factors, its usefulness remains controversial [6,7]. It should be evaluated in populations of different regions and ethnicities before adopting it for routine clinical use. Conflict of interest Report At presenta
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El segundo estudio lo presenta
2019-05-07
El segundo estudio lo presenta Diana Sofía Sánchez, quien aborda de Rosa Beltrán. Texto en el que nos convida de su propuesta basada en: 1 la representación de la familia relacionada con su búsqueda de normalidad, y 2º la reconstrucción puntual de los fracasos y absurdos de la política mexicana. La
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Con respecto de la importancia del periodo colonial
2019-05-07
Con respecto de la importancia del periodo colonial, hay dos ideas en sus reflexiones que quisiera rescatar: la primera es su consideración de esta época como el de la sociedad mexicana, pues es en esta etapa cuando se produce la “creación de una nueva sociedad”, cuyo desarrollo “presenta un materi
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br OPG RANK and RANKL contribute
2019-05-06
OPG, RANK and RANKL contribute to the vicious cycle established between tumour buy something online and bone microenvironment: evidences for sarcomas and carcinomas RANK/RANKL axis is involved in the tumorigenic process RANK/RANKL axis is associated with the bone metastastic process, and as s
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Primary lymphoma of bone is
2019-05-06
Primary lymphoma of bone is an uncommon clinical entity and accounts for less than 5% of malignant bone tumors, 4–5% of extra nodal lymphoma and less than 1% of all non-Hodgkin\'s lymphoma. Diffuse large-B-cell lymphoma (DLBCL) accounts for the majority of cases of PBL [2]. The varied clinical and h
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br Discussion The major finding in
2019-05-06
Discussion The major finding in this case is that implantation of an active-fixation atrial pacing lead in the right atrial appendage caused right coronary artery perforation, resulting in life-threatening tamponade. Myocardial perforation with or without cardiac tamponade has been reported as a
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Of note gender equity might continue despite the economic de
2019-05-06
Of note, gender equity might continue despite the economic development of a society. Studies by Nussbaum and Sen have shown no direct relation between wealth and equity. Hence, some countries with high wealth, such as Saudi Arabia, also a have high degree of gender inequity, whereas others with low
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The TP related complications are given in Table Pericardial
2019-05-06
The TP-related complications are given in Table 3. Pericardial effusion without tamponade was seen in 2 patients (5.9%) in the TEE-guided TP group and 5 (8.8%) in the fluoroscopy-guided group. There was no pericardial tamponade in the TEE-guided group and only one patient experienced tamponade in th
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In addition evidence of similar resting HR
2019-05-06
In addition, evidence of similar resting HR׳s before exercise in the patients and in the controls implies similar autonomic activity at rest during the daytime in both groups of subjects. In contrast, previous studies have reported changes in the nocturnal HR of BrS patients [3,28]. The discrepancy
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