• br Experimental Procedures Additional information can be

  2023-01-10

  

  Experimental Procedures Additional information can be found in Supplemental Experimental Procedures. Author Contributions Acknowledgments We thank all members of Lab of Health Chemistry for helpful discussions. This work was supported by Grant-in-Aid for Scientific Research (KAKENHI) from

• To enhance the accuracy of SEs

  2023-01-10

  

  To enhance the accuracy of SEs in eliminating cancer cells, the mAb recognized by specific Digoxin receptor on tumor cells were fused with SEs. Fab C215 or C242 fused with SEA promoted apoptosis in human colon carcinoma cells via Fas (Dohlsten et al., 1994, Litton et al., 1996). SEB-incorporated ex

• Recently dairy proteins obtained from whey

  2023-01-10

  

  Recently, dairy proteins obtained from whey have received considerable attention for their antioxidant bioactivity (Bayram et al., 2008; Haraguchi et al., 2011; Zhang et al., 2012). Bovine whey proteins (WP) are widely used in various foods for their nutritional, health-promoting, and functional val

• Growth inhibition assays are the most

  2023-01-10

  

  Growth-inhibition assays are the most commonly used to identify antifungal small molecules. However, they have several facts that limit their use since many pathogenic fungi grow as filaments making difficult a correlation between growth and OD (optical density). They are not useful for identifying

• Infections inflammation and corneal transplant can all cause

  2023-01-10

  

  Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid Fmoc-Tyr(tBu)-OH into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the corne

• The clinical impact of our findings is also

  2023-01-09

  

  The clinical impact of our findings is also supported by our earlier report that the level of 12-LOX expression was correlated with the tumor stage and grade [17], [52] and that overall, 38% of patients demonstrated elevated levels of 12-LOX in prostate cancer tissue compared with their matching nor

• To date LOX is the only LOX isoform that

  2023-01-09

  

  To date, 12-LOX is the only LOX isoform that has been identified in the platelet [17]. Interestingly, while 12-LOX is highly expressed (∼14000 molecules/platelet) in the platelet, 12(R)-LOX expression is absent in the hematopoietic lineage and has therefore not been reported to be expressed in plate

• In addition we performed Western blot analysis

  2023-01-09

  

  In addition, we performed Western-blot analysis of different areas of mouse brain with our site against mAck1 (Ureña et al., 2005). The data obtained showed a high rate of expression in neocortex, hippocampus, cerebellum, and brainstem (Fig. 4). More moderate levels of expression were seen in hypot

• Owing to efficient catalytic character high electrolyte acce

  2023-01-09

  

  Owing to efficient catalytic character, high electrolyte accessible area, easy fabrication and many other interesting properties, metal oxide nanoparticles are extensively used in a variety of electro-analytical processes [14]. Metal oxide nanoparticles immobilized over a conductive and large area s

• br Funding br Introduction The

  2023-01-09

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• Previously using a P lacZ reporter gene system it

  2023-01-09

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase hydroxylase when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on the expression of β

• br Disclaimer Statement br Acknowledgments br Introduction M

  2023-01-09

  

  Disclaimer Statement Acknowledgments Introduction Metabolic changes are a common feature of cancerous tissues. Mutations in oncogenes and tumor suppressor genes cause alterations to multiple intracellular signaling pathways that rewire tumor cell metabolism and re-engineer it to allow enhan

• MiR has already been implicated

  2023-01-09

  

  MiR-21 has already been implicated in the protective effects of Res on lung fibrosis, but the molecular mechanisms are underexplored. Our results showed a clear increase of activation protein 1 (AP-1) activity after TGF-β treatment, which was suppressed by Res in a dose-dependent manner, suggesting

• br Antioxidant polymers conjugates Natural antioxidants are

  2023-01-09

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic BMS 961 as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and Kap

• We report here the first study on the inhibitory

  2023-01-09

  

  We report here the first study on the inhibitory effects of the organic nitrates – on human erythrocyte GR. The previous reports by Becker et al., investigated other nitro derivatives (including arylizoalloxazines) by using Beutler’s method, monitoring GR inhibition. Data of show inhibition of hGR

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